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Monday, May 11, 2020 | History

3 edition of Cancer stem cells in solid tumors found in the catalog.

Cancer stem cells in solid tumors

Alison Lawrie Allan

Cancer stem cells in solid tumors

by Alison Lawrie Allan

  • 211 Want to read
  • 23 Currently reading

Published by Humana Press in New York .
Written in English

    Subjects:
  • Cancer cells,
  • Cancer,
  • Molecular aspects,
  • Neoplasms,
  • Neoplastic Stem Cells,
  • Etiology,
  • Stem cells,
  • Physiology

  • Edition Notes

    Includes bibliographical references and index.

    StatementAlison L. Allan, editor
    SeriesStem cell biology and regenerative medicine, Stem cell biology and regenerative medicine
    Classifications
    LC ClassificationsRC269.7 .C377 2011
    The Physical Object
    Paginationxvii, 475 p. :
    Number of Pages475
    ID Numbers
    Open LibraryOL25146408M
    ISBN 101617792454, 1617792462
    ISBN 109781617792458, 9781617792465
    LC Control Number2011932988
    OCLC/WorldCa731915398

      (b) Direct cancer stem cell targeting or (c) indirect cancer stem cell targeting via disruption of their perivascular niche can potentially eliminate cancer stem cells. Ablation of the stem cells may inhibit the regeneration of the tumor and ultimately result in tumor regression. (Source: S. Krishnamurthy and J.E. Nor. Head and Neck Cancer Stem.   Due to their phenotypic resemblance to normal stem cells, the term "cancer stem cells" is used. However, some pieces of the puzzle are missing: (a) a stringent definition of cancer stem cells in solid tumors (b) specific markers that only target cells that meet the criteria for a cancer stem cell in a certain type of tumor.

      Identification of cancer stem cells is possible by detecting expression of a certain combination of various cell surface markers and also by functional assays. The cancer stem cell concept was originally developed for hematological malignancies but is now becoming accepted for solid tumors . Several evidences nowadays demonstrated the critical role of the microenvironment in regulating cancer stem cells and their involvement in tumor progression. Extracellular vesicles (EVs) are considered as one of the most effective vehicles of information among cells. Accordingly, a number of studies led to the recognition of stem cell-associated EVs as new complexes able to contribute to cell Cited by: 3.

    Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem.   The case that a small proportion of cells in solid tumors are specific cancer stem cells and that these cells can be successfully identified and isolated has not yet been proven. (Cancer Res ; 66(4): )Cited by:


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Cancer stem cells in solid tumors by Alison Lawrie Allan Download PDF EPUB FB2

The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these Format: Hardcover.

"Cancer stem cells have moved onto center stage for those who are interested in the behavior of solid tumors. In the context of carcinomas, these cells hold the prospect of explaining many aspects of the malignant behavior of high-grade tumor cells, including their metastatic dissemination and their responsiveness to a variety of : Hardcover.

Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field.

"Cancer stem cells have moved onto center stage for those who are interested in the behavior of solid tumors. In the context of carcinomas, these cells hold the prospect of explaining many aspects of the malignant behavior of high-grade tumor cells, including their metastatic dissemination and their responsiveness to a variety of therapies.

Introduction. The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role Cancer stem cells in solid tumors book stem cells in hematological malignancies and suggested that.

Download Cancer Stem Cells in Solid Tumors PDF The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs).

While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology. Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms.

The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem. Cancer Stem Cells in Solid Tumors (Stem Cell Biology and Regenerative Medicine) eBook: Alison L. Allan: : Kindle Store. Cancer stem cells in solid tumors.

Curr Opin Biotechnol. Oct;18(5) Cancer stem cells in solid tumors. Ailles LE(1), Weissman IL. Author information: (1)Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Arastradero Road, Palo Alto, CAUnited States.

[email protected] Cancer stem cells (CSCs) are cells that drive tumorigenesis, as well as giving Cited by: The CSC field, particularly in the area of solid tumors, is a very young one. A model of solid tumor stem-cell biology is shown in Figure 1, highlighting the properties that are currently viewed as important for tumor growth, and that may represent therapeutic are still in the very technically challenging stage of identifying the methods that will allow us to prospectively isolate Cited by: Request PDF | Cancer Stem Cells in Solid Tumors | The existence of cancer stem cells continues to be extensively debated among scientists, and given the mounting evidence, it is an area that needs.

The Paperback of the Cancer Stem Cells in Solid Tumors by Alison L. Allan at Barnes & Noble. FREE Shipping on $35 or more. Due to COVID, orders may be delayed. Chen W, Zhang X, Chu C, et al. Identification of CD44+ cancer stem cells in human gastric gastroenterology ; 60(): Author: Elizabeth Ortiz-Sánchez.

Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume provides readers with a comprehensive understanding of this important and evolving field.

However, some pieces of the puzzle are missing: (a) a stringent definition of cancer stem cells in solid tumors (b) specific markers that only target cells that meet the criteria for a cancer stem.

Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving : Humana Press. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers.

Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving : Humana Press. Title:Surface Markers of Cancer Stem Cells in Solid Tumors VOLUME: 9 ISSUE: 2 Author(s):Pu Xia Affiliation:Department of Biochemistry and Molecular Biology, School of Basic Medical Science, China Medical University, ShenyangLiaoning, China.

Keywords:Aldehyde dehydrogenase, cancer stem cells, differentiation, surface marker, by: Cancer stem cells (CSCs) have dominated the cancer and stem cell research sector in recent years. CSCs are a subset of tumor cells, found at the center of a tumor mass, possessing the ability to self-renew and differentiate, both characteristics thought to be related to tumor.

Recently, a subpopulation of cells, termed tumor-initiating cells or tumor stem cells (TSC), has been identified in many different types of solid tumors. These TSC, which are typically more resistant to chemotherapy and radiation compared to other tumor cells, have properties similar to normal stem cells including multipotency and the ability to self-renew, proliferate, and maintain the Cited by: This first edition of Stem Cells and Cancer is intended to give a current perspective on the role of stem cells in cancer and strategies for novel therapies directed toward tumor stem cells.

The current cancer stem cell hypothesis is presented in several chapters with distinctions made between the hierarchical and stochastic models of tumor cell development.

"Stemness," self-renewal, pluripotency, clonality, and tumorigenicity are important concepts applied towards defining cancer .Primary tumors are responsible for 10% of cancer deaths. In most cases, the main cause of mortality is the formation of metastases.

Accumulating evidence suggests that a subpopulation of tumor cells with distinct stem‐like properties is responsible for tumor initiation, invasive growth, and metastasis formation.